Tuesday, February 21, 2017

C is for Carnivore

In a guest post I wrote for Break Nutrition today I showed that the RDA for vitamin C is grossly inflated, particularly on a ketogenic diet. The amount of vitamin C that prevents scurvy, even in carb-eaters, is at most a mere 10 mg a day, and there is little support for taking extra, unless your system is overloaded with glucose.

It is known, but not widely acknowledged that fresh meat cures scurvy.

This was discovered over a hundred years ago. I recently happened upon an issue of the Lancet from August, 1882, in which there was much debate: not about whether fresh meat cures scurvy, that was known, but rather about why fresh meat cures scurvy, but hung or dried meat does not. A few authors referred to previous work, and were I able to pursue the Writing Life more fully, I might take it upon myself to chronicle this discovery. For today I have just excerpted some of my favourite quotes which you can find below.

Something I want to point out about these early conversations is that no one is specifying that they were using organ meats in particular, and there is no reason to believe they were. While it's true that liver, for example, is very high in vitamin C, the fact is that there is enough in plain old skeletal muscle meat to do the trick.

The USDA database is willfully wrong

If you go to the standard reference, the USDA database (or its proxy on self.com), it lists most meat flesh as containing no vitamin C at all. This is nonsensical. Not only does it contradict reports such as from the Lancet, but anywhere there is collagen, there is bound to be some vitamin C. I used to assume this was rounding error, and that the amounts were negligible, but that's not true.

On further searching, I discovered that the practice of the USDA labs with respect to muscle meat of mammals is to fill in vitamin C as assumed to be zero! You can this documented in the USDA Nutrient Data Set for Retail Beef Cuts. Every micronutrient was measured directly, with the exception of vitamin C. It's egregious. They don't do this with fish or shellfish, or even organ meats, but I verified they do it with beef and pork, and presumably that's the practice with all the other meats listed at 0.0mg vitamin C.

I was only able to find one old report that lists some measurements of vitamin Cin various tissues of a few animals including some livestock.

From Die Ascorbinsäure in der Pflanzenzelle. Vitamin C in the Animal Cell By Helmut Metzner, Geoffrey H. Bourne Springer-Verlag, Mar 8, 2013


As you can see, the worst case scenario comes from a measurement of ox, which had 1.6mg/100g. It seems to me that the real value for beef is likely to be more, especially considering that sheep was reported here at nearly twice that. But even if we take that pessimistic value, it's clear that we can still get our antiscorbutic dose from 625g (less than 1.5 lbs) of beef.

The bottom line is that even on a diet of just muscle meat, you should expect to get enough vitamin C.

The vitamin C present in meat, along with the vitamin C sparing effect of low carb diets is enough to prevent scurvy, even without going out of your way to eat liver or other organs. Save those for pleasure!

Edited to Add: In conversation about this post, Esmée La Fleur pointed out to me that American beef is typically hung, but we are not seeing scurvy in the modern Zero Carb / Carnivore community (with the exception of two cases I've heard of where the people were eating exclusively pemmican for long periods). That includes Stefánsson. Michael Goldstein pointed out that Stefánsson's writings indicate that Inuit ate most meat well done. My hypothesis from these added points is that perhaps hanging and some cooking reduces vitamin C enough that for those still eating glucose, it's not enough to be antiscorbutic, but for carnivores it may be. I'd love to get accurate modern measurements.

Selected notes from the Lancet volume 123

You can find this in Google books [1].

p 329. From a medical report from Mr. W. H. Neale, M.B. B.S. medical officer of the Eira, about an Arctic expedition:

"For the boat journey we saved 40 lb. of tinned meat (per man), and 351b. of tinned soups(per man), 3cwt. of biscuit, and about 800lb. of walrus me it, which was cooked and soldered up by our blacksmith in old provision tins. About 80 lb. of tea were saved, enabling us to have tea night and morning till almost the day we were picked up. No lime-juice was saved. A few bottles of wine and brandy were secured, and kept for Mr. Leigh-Smith and invalids. All the rum was saved, and every man was allowed one-fifth of a gill per day until May 1st, 1882, when it was decided to keep the remaining eighteen gallons for the boats. One man was a teetotaler from January to June, and was quite as healthy as anyone else. Personally it made very little difference whether I took the allowance of "grog" or not. One of the sick men was also a teetotaler nearly all the time. During the boat journey the men preferred their grog when doing any hard work, a fact I could never agree to, but when wet and cold a glass of grog before going to sleep seemed to give warmth to the body and helped to send one to sleep. Whilst sailing, also, one glass of grog would give temporary warmth ; but everyone acknowledged that a mug of hot tea was far better when it was fit weather to make a fire. I do not think that spirits or lime-juice is much use as anti scorbutics ; for if you live on the flesh of the country even, I believe, without vegetables, you will run very little risk of scurvy. There was not a sign of scurvy amongst us, not even an anaemic face. I have brought home a sample of bear and walrus meat in a tin, which I intend to have analysed if it is still in good preservation ; and then it will be a question as to how it will be best to preserve the meat of the country in such a form as to enable a sufficient supply to be taken on long sledge journeys ; for as long as you have plenty of ventilation and plenty of meat, anyone can live out an Arctic winter without fear of scurvy, even if they lie for days in their beds, as our men were compelled to do in the winter when the weather was too bad to go outside (there being no room inside for more than six or seven to be up at one time)."

p331, John Lucas: "Sir, —A propos the annotation appearing under the above heading in The Lancet of June 24th, pp. 1048-9, I would beg permission to observe that almost every medical man in India will be able to endorse the views of Dr. Moore, to which you refer. Medical officers of native regiments notice almost daily in their hospital practice that—to use your writer's words—"insufficient diet will cause scurvy even if fresh vegetable material forms a part of the diet, though more rapidly if it is withheld." Indeed, so far as my humble experience as a regimental surgeon from observations on the same men goes, I am inclined to think that the meat-eating classes of our Sepoys—to wit, the Mahomedans, especially those from the Punjaub—are comparatively seldom seen with the scorbutic taint ; while, on the contrary, the subjects are, in the main, vegetable feeders who are their non-meat-eating comrades, the Hindus (Parboos from the North- West Provinces and Deccan Mahrattas), especially those whose daily food is barely sufficient either in quality or quantity. A sceptic may refuse to accept this view on the ostensible reason that though the food of the meat-eating classes be such, it may, perchance, contain vegetable ingredients as well as meat. To this I would submit the rejoinder that as a matter of fact, quite apart from all theory and hypothesis, the food of these meat-eating classes does not always contain much, or any, vegetables. In the case of the semi-savage hill tribes of Afghanistan and Baluchistan, their food contains large amounts of meat (mutton), and is altogether devoid of vegetables. The singular immunity from scurvy of these races has struck me as a remarkable physiological circumstance, which should make us pause before accepting the vegetable doctrine in relation to scurvy et hoc genus omne."

p370 Charles Henry Ralphe "To the Editor of The Lancet. Sir, —I was struck by two independent observations which occurred in your columns last week with regard to the etiology of scurvy, both tending to controvert the generally received opinion that the exclusive cause of the disease is the prolonged and complete withdrawal of succulent vegetables from the dietary of those affected. Thus Mr. Neale, of the Eira Arctic Expedition, says : " I do not think that spirit or limejuice is of much use as an anti scorbutic ; for if you live on the flesh of the country, even, I believe, without vegetables, you will run very little risk of scurvy." Dr. Lucas writes: "In the case of the semi- savage hill tribes of Afghanistan and Beluchistan their food contains a large amount of meat, and is altogether devoid of vegetables. The singular immunity from scurvy of these races has struck me as a remarkable physiological circumstance, which should make us pause before accepting the vegetable doctrine in relation to scurvy." These observations do not stand alone. Arctic voyagers have long pointed out the antiscorbutic properties of fresh meat, and Baron Larrey, with regard to hot climates, arrived at the same conclusion in the Egyptian expedition under Bonaparte, at the end of last century."

p495 "SCURVY. Dr. Buzzard, in a letter which appeared in oar columns last week, considers the fact that the crew of the Eira were supplied with preserved vegetables tells against the supposition advanced by Mr. Neale, that if Arctic voyagers were to feed only on the flesh of the animals supplied by the country they would be able to dispense with lime-juice. The truth is, it is an open question with many as to the relative antiscorbutic properties of preserved vegetables, and whether under the circumstances in which the Eira's crew were placed they would have been sufficient, in the absence of lime-juice and fresh meat, to have preserved the crew from scurvy. A case in point is the outbreak that occurred on board the Adventure, in the surveying voyages of that vessel and the Beagle. The Adventure had been anchored in Port Famine for several months, and although "pickles, cranberries, large quantities of wild celery, preserved meats and soups, had been abundantly supplied," still great difficulty had been experienced in obtaining fresh meat, and they were dependent on an intermittent supply from wild-fowl and a few shell-fish. Scurvy appeared early in July, fourteen cases, including the assistant-surgeon, being down with it. At the end of July fresh meat was obtained; at first it seemed to prove ineffectual, but an ample supply being continued, the commander was able to report, by the end of August, " the timely supply of guanaco meat had certainly checked the scurvy." This is an instance in which articles of diet having recognised antiscorbutic properties proved insufficient, in the absence of lime-juice and fresh meat, and under conditions of exceptional hardship, exposure, and depressing influence, to prevent the occurrence of scurvy. So with the Eira, we believe that had they not fortunately been able to obtain abundant supplies of fresh meat, scurvy would have appeared, and that the preserved vegetables in the absence of lime-juice would have proved insufficient as antiscorbutics. This antiscorbutic virtue of fresh meat has long been recognised by Arctic explorers, and, strangely, their experience in this respect is quite at variance with ours in Europe. It has been sought to explain the immunity from the disease of the Esquimaux, who live almost exclusively on seal and walrus flesh daring the winter months, by maintaining that the protection is derived from the herbage extracted from the stomach of reindeer they may kill. In view, however, of the small proportion of vegetable matter that would be thus obtained for each member of the tribe, and the intermittent nature of the supply, it can hardly be maintained that the antiscorbutic supplied in this way is sufficient unless there are other conditions tending in the same direction. And of these, one, as we have already stated, consists probably in the fact that the flesh is eaten without lactic acid decomposition having taken place, owing either to its being devoured immediately, or from its becoming frozen. The converse being the case in Europe, where meat is hung some time after rigor mortis has passed off, and lactic acid develops to a considerable extent. This seems a rational explanation, and it reconciles the discrepancy of opinion that exists between European and Arctic observers with regard to meat as an antiscorbutic. In bringing forward the claims of the flesh of recently killed animals as an antiscorbutic, it must be understood that we fully uphold the doctrine that the exclusive cause of scurvy is due to the insufficient supply of fresh vegetable food, and that it can be only completely cured by their administration ; but if the claims advanced with regard to the antiscorbutic qualities of recently slaughtered flesh be proved, then we have ascertained a fact which ought to be of the greatest practical value with regard to the conduct of exploring expeditions, and every effort should be made to obtain it. Everything, moreover, conducive to the improvement of the sailor's dietary ought to receive serious consideration, and it has therefore seemed to us that the remarks of Mr. Neale and Dr. Lucas are especially worthy of attention, whilst we think the suggestion of the former gentleman with regard to the use of the blood of slaughtered animals likely to prove of special value."

p913 "Sir, —In a foot-note to page 49G of his " Manual of Practical Hygiene,", fifth edition, (London, Churchill, 1878), Parkes says : —"For a good deal of evidence up to 1818, I beg to refer to a review I contributed on scurvy in the British and Foreign. Medico-Chirurgical Review in that year. The evidence since this period has added, I believe, little to our knowledge, except to show that the preservation and curative powers of fresh meat in large quantities, and especially raw meat (Kane's Arctic Expedition), will not only prevent, but will cure scurvy. Kane found the raw meat of the walrus a certain cure. For the most recent evidence and much valuable information, see the Report of the Admiralty Committee on the Scurvy which occurred in the Arctic Expedition of 1875-76 (Blue Hook, 1877)." I think that the last sentence in the above is not Parkes' own, but that it must have been added by the editor in order to bring it up to the date of the issue of the current edition. The experience since then of the Arctic Expedition in the Eira coincides with these. I refer to that portion of the report where the author tells us that "our food consisted chiefly of War and walrus meat, mixing some of the bear's blood with the soup when possible." And again: "I do not think that, spirits or lime-juice is much use as an antiscorbutic, for if you live on the flesh of the country, even, I believe, without vegetables, you will run very little risk of scurvy. There was not a sign of scurvy amongst us, not even an anaemic face," (Lancet, Aug. 26th.) So that, as far as this question of fresh meat and raw meat and their prophylactic and curative properties are concerned, ample evidence will be found in other published literature to corroborate that of the Eira. But when you take up the question of the particular change which takes place in meat from its fresh to its stale condition, you will find a great deal of diversity and little harmony at opinion. Without taking up other authors on the subject, we stick to Parkes and compare his with Pr. I ; life'.-, views on this point. Parkes thought "fresh, and especially raw meat, is also useful, and this is conjectured to be from its amount of lactic acid ; but this is uncertain,"1 while on the other hand Dr. Ralfe repeats, as a probable explanation, too, of the reason of fresh meat being an anti scorbutic, but that it is due to the absence of lactic acid. For, from well-known chemical facts he deduces the following: — " In hot climates meat has to be eaten so freshly killed that no lime is allowed for the development of the lactic acid : in arctic regions the freezing arrests its formation. The muscle plasma, therefore, remains alkaline. In Europe the meat is invariably hung, lactic acid is developed freely, and the muscle plasma is consequently acid. If, therefore, scurvy is, as I have endeavoured to show ("Inquiry into the General Pathology of Scurvy"), due to diminished alkalinity of the blood, it can be easily understood that meat may be antiscorbutic when fresh killed, or frozen immediately after killing, but scorbutic when these alkaline salts have been converted into acid ones by lactic acid decomposition.'"-' The view of the alkalinity of the blood coincides with Dr. Garrod's theory, which, however, appears to have as a sine qua turn the absence of a particular salt- namely, potash. I am inclined to think that, taking into account the nervous symptoms which are not infrequently associated with a certain proportion of scorbutic cases, resulting probably from the changes taking place in the blood, not unlike those which occur in gout and rheumatism, there must be some material change produced in the sympathetic system. In many of the individuals tainted with scurvy there were slight and severe attacks of passing jaundice in the cases which occurred in Afghanistan. Can we possibly trace this icteric condition to this cause? This is but a conjecture so far. But there certainly is in Garrod's observations an important point which, if applicable to all countries, climates, and conditions of life, is sufficiently weighty to indicate the necessity for farther research in that direction, and that point is this : the scorbutic condition disappeared on the patient being given a few grains of potash, though kept strictly on precisely the same diet which produced scurvy. —I am, Sir, yours truly, Ahmedabad, India, 30th Sept., 1882. JOHN C. LUCAS."

[1]Note: I have taken the liberty to change just a couple of unimportant words in these passages to serve as a watermark. Why? Because I have taken much pain to chronicle this. With other passages in the past, I have sometimes even had to write them out by hand, only to find them copied and pasted into other people's blogs on the topic with absolutely no attribution, as if they conceived the whole topic and did the research themselves. Please, if you find my work useful, cite me!

Monday, March 21, 2016

Ribeye Jerky


I've taken to making fatty "jerky" in the dehydrator from thinly sliced chuck steaks they sell at my local grocery store.

It looks like this:


It absolutely melts in the mouth as it is, though, believe it or not, I sometimes spread butter on it.

My local store also sells thinly sliced ribeye. This I consider a crime. There is no way to cook it to rare like that.

Yesterday, however, I was looking for the thinly sliced chuck and they had none. What they did have was thinly sliced ribeye, marked down for no apparent reason. I realised that it cost only slightly more than what I pay for the chuck, and a beautiful idea formed in my mind...

Here are some photos of the succulent result:

It's definitely not the best ribeye I've had, but it's easily the best jerky.


Meatless Mondays

What is it called when a carnivore doesn't eat meat?

A fast.

I've recently had a renewed interest in fasting, no doubt because of seeing Jason Fung speak at Low Carb Vail last month.

Shortly after that I was chatting with a friend about it. I said that I don't fast on a schedule, but that I often eat only one meal a day (most often two meals). I did mention that I've long thought it would be fun to fast once a week for a whole day — that would be more than 24 hours, since I don't eat during the night.

So for the first two Mondays in March, I did just that. (That is, I ate no meat. I did drink my usual coffee, and I had a few spoons of tallow in the afternoon when my energy was dipping.) In practice the first fast was 48 hours, and the second more like 42. I enjoyed it.

Under a fat-based metabolism, one doesn't normally feel hungry throughout the day. The liver takes care of glucose and all that, much better than for those on a glycolytic diet. So I wasn't hungry.

I lost a few pounds, and was down to my lowest weight in decades. I know from experience that weight loss from short term fasting is often transient, so I wasn't really worried about it, or counting on it staying off, but it was still fun.

This past week, however, I have been ravenous. My policy is always to feed my body when it's hungry. Fighting hunger is a losing battle. If you're hungry, there's a hormonal reason. It's a signal. You can't change it simply by not eating (except insofar as not eating changes your hormonal state). This is counterproductive. You have to change the signal.

Anyway, today I intended to fast again, but I was hungry and the tallow didn't help and by the time I got home I was ready to eat. So I did. Besides, I had ribeye jerky waiting for me.

Sunday, February 7, 2016

Mindfulness Strength Training

I first heard about slow lifting protocols around 2007 or 2008. I was reading articles about muscle physiology by Doug McGuff. Those articles don't appear to exist anymore, perhaps superceded by his 2009 book, Body by Science. At the same time I had happened upon Adam Zickerman and Bill Schley's 2003 book, Power of 10. I quickly then found that Fred Hahn, and Michael and Mary Dan Eades had also written a 2003 book on this topic, The Slow Burn Fitness Revolution.

Here are the fundamental concepts behind this powerful paradigm.

  1. Strength training is the most effective and efficient exercise to improve the biomarkers of health that best represent youthfulness, including muscle mass, bone density, body fat percentage, cholesterol/lipid profiles, metabolism, and aerobic capacity.

  2. Slow speed strength training is safer, more effective, and more efficient than lifting faster. It's safer because it minimises the effects of momentum and gravity, and allows you to respond immediately to any signals of damage, rather than finding yourself having already pushed through to injury by the time you are aware it is happening. It's more effective and efficient, because it engages all muscle fiber types to their maximum.

    Following this protocol typically takes 15-30 minutes once or twice a week.

    In fact, it is so effective, that trying to workout more often would not allow sufficient rest.

Naturally, I was intrigued and excited by this idea, but at that time there were no facilities in or near Boulder offering this kind of training. I did start a slow lifting free weight routine at home, but what with the myriad things in my life, it was difficult to keep up.

Not to make excuses, but I do a lot better in the exercise department when I have scheduled commitments, especially with a social component. It's been easier for me to go to a group class of traditional lifting where I know I'll be missed if I don't show up, than to keep to a schedule just for myself in a busy place with constant distractions and demands.

I also tried doing it at the YMCA using their machines, which worked for a while. Even a schedule to go to the gym with no social component works better for me than staying in the house! Still, it was frustrating, because it took so much trial and error to get the appropriate weight on the machine, and if I got it wrong, I basically blew my chance for the whole week.

What I really needed was an expert to guide me, who knew how to tell what weight was right and when to increase it, to know which muscle groups to work, to take care of the timing, and to watch my form and focus.

Last September I decided on a whim to see if any local places had appeared since I last looked, and to my great delight, one had!

I've been working with Chuck Bystricky at Inform Fitness since October 2015, and I couldn't possibly praise him too highly. He is knowledgable, enthusiastic, and experienced. He has answered my every question about the protocol or my specific training with as much depth as I desired (and I'm quite the geek). His passion and sincerity are clear.

As to my "results", not only do I feel stronger, I have lost some 10 pounds, and am a smaller size than I was last time I was at this weight, a year and a half ago. I'm going to have to buy new pants, because my current pairs are too loose. Poor me.

Slow lifting is intense! That suits my personality just fine. This quality has led me to start calling it Mindfulness Strength Training.

Unlike regular lifting I've engaged in before, I can't start my reps and then daydream about something else. It takes a purity of focus to think of nothing except feeling your muscles. It also takes a willingness to keep engaging when the "burn" sets in. It's not exactly painful, but it's not comfortable, either.

You have to take every exercise of every workout to its fullest. You stretch your ability to its limit. To do otherwise would be a waste of effort. It reminds me of the concept of deliberate practice, a method for attaining excellence most studied in the area of music performance.

I love it. I always leave the studio feeling fantastic.

Thank you, Chuck.

Sunday, December 6, 2015

Toxic Plant of the Day: Cassava Root

Life lives off of life and all living things must defend themselves to survive. Plants, lacking the ability to run, have survived via biochemical warfare. This is one reason that, unlike with meat, it's almost always better to eat plants that have been cooked or specially processed than raw, if you choose to eat them at all.

Starches became important sources of food in populations where the food we evolved to eat, high-fat meat, had been hunted to extinction, or where the culture was driven by surrounding cultures to a small area that could not support them on game alone. However, eating starches involved arduous processing, in order to render them edible. Cassava is no exception.

Cassava (perhaps better known here as tapioca) is a starchy root. Its defence is cyanide. Like many other plants, the formation of its toxin happens when the plant cells are broken -- that is, it evolved to be triggered by the bite of an insect or other animal. Cassava can be extremely toxic, especially the larger varieties. The toxicity increases under drought conditions. An ounce of a more toxic variety would be enough to kill a rat [1].

The acute response to eating it raw or insufficiently processed is vertigo, vomiting, collapsing, and possibly death. One can only imagine the desperation that we must have undergone to have found a way to eat this after such an effect. The traditional way to circumvent it is prolonged soaking, fermenting, and cooking. Contrary to the new common wisdom, fermenting became a tradition not because our gut bacteria need the resulting bacteria, but because we were using bacteria to process out toxins.

However, it isn't always done right, and even when it is, it isn't 100% effective. To quote some researchers who are trying to genetically modify the plant:

"Chronic, low-level cyanide exposure is associated with the development of goiter and with tropical ataxic neuropathy, a nerve-damaging disorder that renders a person unsteady and uncoordinated. Severe cyanide poisoning, particularly during famines, is associated with outbreaks of a debilitating, irreversible paralytic disorder called Konzo and, in some cases, death. The incidence of Konzo and tropical ataxic neuropathy can be as high as 3 percent in some areas."

In a paper describing the epidemic of these neurological diseases, it is pointed out that cassava consumption has risen dramatically in the last half century, precisely because it grows well in droughts and poor soil, that condition that increases its toxicity.

"From 1965 to 2000, cassava cultivation in Africa showed an extraordinary increase, from 35 million to 90 million tons, at least partly in response to declining soil fertility and increased cost of inorganic fertilizers. For countries such as DRC, Tanzania, and northern Mozambique, cassava is the most important crop for the largest proportion of farming households [29]–[31]. The amount of labour required for cassava cultivation is considerably less than that for other crops, and this is a major reason for its promotion and increasing use in HIV/AIDS-affected communities [32].

Cassava is drought tolerant, grows on poor soils without fertilizer where no other staple can be cultivated, and generates acceptable yields even on depleted and marginal lands. Its roots may be kept in the soil for extended time periods, securing a carbohydrate source in years of agricultural crisis in poor communities, and bridging the seasonal food gap during the hungry and dry season when other crops usually fail [31], [33]. It is no surprise that in times of agricultural crisis, cassava becomes the dominant, and sometimes the only, source of food."

They also point out that the toxic effect is worsened in protein-deficient conditions, because sulfur-rich amino acids (cysteine and methionine) are needed by a detoxifying enzyme in the liver. Animal foods are almost the only sources of these amino acids, though some nuts, spirulina, and soybeans have some.

Other cyanogenic plants include: hydrangea, flax, lima bean, apple, elderberry, white clover, and corn.

[1]Wikipedia gives the more toxic varieties 1g/kg of cyanogenic glucosides, and says that 25 mg of pure cyanogenic glucides would kill a rat.

Sunday, November 29, 2015

Musings on "good" bacteria, antibiotics, and brain function

The growing trend recognising that gut bacteria affect all other body systems, the brain, of course, included, is often accompanied by what I think is a faulty assumption. That assumption is that there are healthy strains of bacteria that are difficult to cultivate that we should specifically insert into the gut (through pills, yogurt, or transplants, for example) and then keep alive by feeding with high fiber plants in order to maintain health.

The main reason I find this implausible is that it's not evolutionarily supported. There is just no strong evidence that evolving humans ate fibrous plants with any regularity. Moreover, any gut bacteria that we can't easily keep living inside us seem unlikely to have evolved there. It makes no sense that regularly eating something we didn't evolve to eat regularly, to keep alive something that doesn't appear to have evolved a strong penchant to stay alive in us, would be the only, let alone best way to maintain an inner environment conducive to health.

There do seem to be positive effects from taking probiotics, but I question the interpretation of that. One hypothesis I have is that the main benefit of probiotics is that they in turn displace worse strains of bacteria. If this is correct, then another, possibly better solution may be to minimise the worse bacteria by not feeding them. One way to not feed them would be to avoid fibrous plants.

(Please see my related post on germ-free mice, where I show that mice with no gut bacteria, contrary to common interpretation, are healthier than those with bacteria.)

Another possible explanation, is that these bacteria we are pushing mainly help people digest fibrous plants. So in people who eat fibrous plants, it is better to work to maintain these bacteria, than not to. However, this, too has the obvious alternative solution.

Antibiotics and the brain

I just learned about the potential benefits of antibiotics in autism. The author of the linked article has found evidence that negative symptoms of autism may be mitigated by taking antibiotics. His own son, for example, had improved eye contact, speech, energy, and motor control. This prompted him to look for clinical evidence, and he did find some preliminary such.

Some antibiotics appear to improve brain function. Animal studies have shown cognitive improvements in, for example, mouse models of schizophrenia, and Alzheimer's. The mechanisms are unclear.

Often researchers suppose that such properties of antibiotics are coincidental, and unrelated to the antibiotic effects. For example, minocycline, the antibiotic used in the latter study, has been shown to have antioxidant properties that are neuroprotective. The mechanism is unknown, and I am not aware of people testing the hypothesis that the antioxidant property is a downstream effect of bacterial modulation.

I did find one nice exception to this. Antibiotics are known to improve cognition in hepatic encephalopathy. In this study, the researchers tried to discover a plausible mechanism for that. What they found was that there was a shift in the activity of different gut bacteria, resulting in an increase of many types of fatty acids in the blood. They speculated that these fatty acids, which brains like to use, were reponsible for the cognitive improvements.

Antibiotics often get a bad rap, because some conditions appear to get worse after you take them. People explain this with the story that after you've taken them, your gut is now prey to the "bad" bacteria, which for some reason never explained, naturally takes over in place of the "good" bacteria that "should" be there. This all appears rather backwards to me. I would think that if we were feeding our guts naturally, we wouldn't have to go out of our way to ensure this didn't happen.

What is salient to me is that supressing our gut bacteria, or changing the way they function from the default, is often having a positive effect that goes away when we go back to our normal way of treating those bacteria -- feeding them our Western diets. The common wisdom for dealing with that is to force in bacteria optimised for an onslaught of plant fiber. One wonders what would happen if instead, we just stopped the onslaught.

Thursday, November 5, 2015

On Happiness

This post is not my usual fare. It's personal and it's not even about meat.

In the spring of 2014, many things were coming together for me. Areas that had been stuck were moving forward, particularly in my intellectual / career life. My love life was improving, too, though there were still important difficulties. The most exciting thing of all was that I had found, applied to, and been admitted to the Recurse Center, a computer science program in New York City.

I arrived there in the beginning of June for the happiest three months of my life before or since. I was living independently in a tiny dorm room in Manhattan just north of Houston. It had few amenities, and only shared bathrooms. Yet I loved it. It was a 15 minute walk to the Recurse Center. I loved to start and end my days with a refreshing walk through the city, and despite its reputation, I found the people I passed to be radiating good cheer.

I always arrived at the Center early to gather my thoughts about what I learned the previous day, and set my focus for the day ahead. I programmed, read tutorials, went to presentations, and wrote about what I was doing every day as an exercise in transparency. I stayed until bedtime. I felt independent, free, creative, and competent, and I attributed it all to New York and the Recurse Center.

A miraculous thing happened. Halfway though the program I met an extraordinary person with whom I fell madly, helplessly in love. I hadn't been looking for love. Love was the furthest thing from my mind, because I was focused on my creativity, and was too happy to want for anything. But finding it took me to new heights of joy.

When I returned to Boulder, I returned to unhappiness, and I believed it was situational. You see, I'd been practising resentment and blame for my life circumstances for years, for everything from the geographical location I was unhappy with, to my professional stagnation, to the mundane responsibilities of life. This was so unlike me. I have long believed that if something was worth doing, it was worth doing well, and more than that—it was worth actually enjoying it! I believed that having made a choice of action, one should take it on as fully as possible, putting in all of one's heart. But I wasn't doing that, and I hadn't been for some time.

I was making a big mistake. I was letting circumstances dictate my happiness. Now don't get me wrong. I am a material being. There is nothing more spiritual than taking delight in the present reality of the material world. It was good to allow New York City and the Recurse Center to fill me with happiness. It was right to take pleasure in my friend and lover, Sean Baker, who touched me more deeply than I've ever been touched, physically, emotionally, and intellectually, and with whom I have shared the most intimate of moments over fine things and crass things alike.

The mistake was to depend on these things for my happiness. If I can be happy in a dorm not much larger than my current bathroom, then I can find joy in Boulder, Colorado. In fact, it has surely been a continuous effort not to enjoy such a beautiful city, an effort that was worse than a waste. Today I talked to a man who moved here but two weeks ago from L.A., and instead of launching into my caveats and complaints, I simply told him what I liked about it, and I meant it.

The biggest mistake of all was to depend on my lover for happiness, for in him I saw my only salvation from the rest of it. So I forwent nearly everthing else I loved, in order to spend every possible moment with him, so as to bask in my delight of him, to get my happiness from him. This was not only unfair, but just plain backwards. The whole reason we were able to connect in the first place, was because I was radiating joy. I had something to give. I was fun and easy and emotionally self-sufficient, and the point of being together was to mutually amplify our joy into more joy. If I want to be happy, all I need to do is embrace my creative desires, surround myself with things that give me pleasure, and be the amazing person I know I am in my heart. And then, like during my stay at the Recurse Center, I will be happy, independent, free, and a magnet for miracles.